Torbay Council want to improve the support offered to Torbay-based pharmacies providing Naloxone and increase the distribution of Naloxone by simplifying our Pharmacy Naloxone model. They would like to standardise the pharmacy Naloxone offer by commissioning 1 type of Naloxone, either Prenoxad (injectable form) or Nyxoid (nasal form). They would value the opinion of any Torbay-based pharmacies to help them decide which type of naloxone to commission within Torbay’s pharmacy contract specification from 2025. Please answer 2 very simple questions using the form here to assist them in this decision.
Below is a brief summary of the benefits and potential challenges for the types of Naloxone being considered (note that the nasal pebble is not being considered as an option for this commission):
Prenoxad – Injectable Naloxone
· Fast onset of action (2-5mins).
· high bioavailability and a long duration of action (typically lasts between 30 and 90minutes).
· Provides up to 2ml of Naloxone (5 x .4ml doses), tailoring it to the specific needs of the individual, reducing risk of aggressive awakening.
· Requires assembly of a needle for administration - could cause a needle stick injury to the person administering the drug.
· The needle could be removed and used for other purposes by the client.
· It is invasive as is delivered intramuscularly.
· Carry case may not be pocket friendly.
· Non-invasive method.
· Design supports quicker intervention in overdose situations.
· Provides total of 3.6 ml of Naloxone (2 x 1.8mg doses).
· Provided in a compact portable device.
· Slower onset of action (5-20 mins).
· Lower bioavailability, meaning less of the drug is absorbed into the bloodstream.
· Unable to administer in doses, increasing risk of aggression on awakening.
· Carrying both doses provides less naloxone than carrying 1 injectable naloxone kit.